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National Institute of Biology (NIB), Ljubljana, Slovenia

 


www.nib.si

Contact person
Metka Filipič
Email address
metka.filipic@nib.si

Postal address
Večna pot 111, 1000 Ljubljana, Slovenia
Phone number
+386 (0)5 523 28 61
+386 (0)41 741 420

 

 

NIB is a public non-profit research institute. The mission and core activity of NIB is basic and applied research in various areas of biology (microbial ecology, plant and animal physiology, etc.), environmental sciences, biomedicine, systems biology and biotechnology. The Department of Genetic Toxicology and Cancer Biology (GEN) has key expertise in genetic toxicology. The studies are focused on exploring the mechanisms of genotoxicity of dietary carcinogens, natural toxins and manmade pollutants. In the field of water research GEN has also long-standing expertise in environmental biomonitoring of microinvertebratae. The Department of Biotechnology and Systems Biology (FITO) has expertise in the use of system biology tools for the study of the physiology of plant-pathogen interaction and drug development and production, in development of novel diagnostic methods for detection of plant and other pathogens and their diagnosis. FITO has also accredited laboratories (according to ISO17025) for qualitative and quantitative detection of genetically modified organisms in food and feed, using real-time PCR for quantitative detection.

The Department of Genetic Toxicology and Cancer Biology (GEN) has key expertise in genetic toxicology; GEN studies are focused on exploring the mechanisms of genotoxicity of dietary carcinogens, natural toxins and manmade pollutants. In the field of water research GEN has also longstanding expertise in environmental biomonitoring of microinvertebratae. Main research tools are in vitro biological and molecular methods, and recently also models with zebrafis embryos. For studying the mode of action of different types of toxicants GEN research team uses classical toxicity and genotoxicity test methods associated with novel toxicogenomic methods such as DNA microarrays and RT-PCR. The department is equipped with modern laboratories including the whole range of equipment for molecular biology, cell culturing, and toxicity/genotoxicity testing. They are equipped with fluorescent microscopy with computer aided image analysis system, spectrofluorimeter, flow cytometer, RT-PCR, and have access to confocal microscopy, and to micro array platform. Since 2006 the departments GEN and FITO are involved in the bilateral Inremos project SYSTHER, focusing on systems biology tools development for cell therapy and anticancer drugs.

The Department of Biotechnology and Systems Biology (FITO) has expertise in the use of system biology tools for the study of the physiology of plant-pathogen interaction and drug development and production, in development of novel diagnostic methods for detection of plant and other pathogens and their diagnosis. FITO has accredited laboratories (according to ISO17025) for qualitative and quantitative detection of genetically modified organisms in food and feed, using real-time PCR for quantitative detection. FITO collaborates with the pharmaceutical industry on implementation of molecular biology methods in drug design and production improvement. The Department’s laboratories are equipped for molecular biology, biochemical and microbiological analysis, growth chambers, experimental greenhouses and electron microscopy.

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