Objectives

1.To develop new analytical methods for assessment of the occurrence and fate of cytostatic pharmaceuticals, their metabolites and transformation products in water treatment systems and in the environment.

2.To explore potential delayed and irreversible effects of cytostatic pharmaceuticals at environmentally relevant concentrations in aquatic experimental models, and compare the data to those obtained in human experimental models.

3.To explore combined effects of mixtures of cytostatic pharmaceuticals, their excreted metabolites and transformation products formed in the environment and/or waste water treatment.

4.To develop, based on the obtained results, guidance on how to improve the environmental and human risk assessment of cytostatics released into the environment.

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